Mechanisms, model assumptions, validation criteria, and literature behind the general program pages.
The main site explains what Virelion is building. These pages explain the biology, engineering constraints, model assumptions, evidence hierarchy, and failure modes behind that work. They are intentionally more technical and separate established literature from Virelion’s own research-stage hypotheses and software architecture.
Why the adult mammalian heart regenerates poorly, what counts as true cardiomyocyte renewal, and how proliferation, reprogramming, cell replacement, fibrosis, metabolism, and the immune niche fit together.
Open biology →Target classes, myocardial delivery, transient versus persistent expression, safety constraints, candidate ranking, and preclinical gates relevant to VB-101.
Open gene therapy →Mechanical matching, anisotropy, electrical integration, vascularization, degradation, immunologic interaction, and patch-versus-hydrogel tradeoffs relevant to VB-204.
Open biomaterials →Patient-specific anatomy, electrophysiology, mechanics, parameter inference, uncertainty, calibration, virtual intervention, and endpoint-specific validation around HeartTwin.
Open digital twins →How omics, perturbation data, literature, disease models, target tractability, cross-species consistency, and provenance can converge into a ranked experimental dossier.
Open discovery →Assay reproducibility, leakage-resistant ML, external validation, mechanistic-model verification, uncertainty quantification, and claim-specific translational gates.
Open validation →